カタログ製品コード : C-EK1261-96
Human B7-H1/PD-L1/CD274 ELISA kit
| 24T | ¥70,200 | (¥2,925/T) (税別) |
| 48T | ¥84,200 | (¥1,754/T) (税別) |
| 96T | ¥93,000 | (¥969/T) (税別) |
標準納期 : 2週間 |
製品詳細
| メーカー名 | 遺伝子名 | 種交差性 | 測定範囲 | サンプル量 | 適用サンプル | ドキュメント |
|---|---|---|---|---|---|---|
| MultiSciences | B7-H1/PD-L1/CD274 | Human | 234.38 - 15000 pg/ml | 50 μl | 血清、血漿、細胞培養上清 |
|
■保存方法 :
キットは未開封の場合、4℃で保管すること。 開封後は標準溶液を-20℃で保存し、他の試薬は4℃で保存すること。
■構成内容 :
| 96-well polystyrene microplate coated with a monoclonal antibody against B7-H1 |
| Human B7-H1 Standard, lyophilized |
| B7-H1 Detect Antibody |
| Standard Diluent |
| Streptavidin-HRP |
| Assay Buffer (10×) |
| Substrate (TMB) |
| Stop Solution |
| Washing Buffer (20×) |
| Plate Covers |
■キーワード :
Homo sapiens,Human,Programmed cell death 1 ligand 1,PD-L1,PDCD1 ligand 1,Programmed death ligand 1,B7 homolog 1,B7-H1,CD274,B7H1,PDCD1L1,PDCD1LG1,PDL1,CD274
■ターゲット情報 :
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human B7-H1. The Human B7-H1/PD-L1/CD274 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
B7 homolog 1 (B7-H1), also known as programmed death-ligand 1 (PD-L1) and cluster of differentiation 274 (CD274), is a 40kDa type I transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of B7-H1 to its receptor transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes.
Upregulation of B7-H1 may allow cancers to evade the host immune system. An analysis of 196 tumor specimens from patients with renal cell carcinoma found that high tumor expression of B7-H1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death. In addition, B7-H1 acts as a positive costimulatory molecule in intracellular infection. In humans, B7-H1 was found to have altered expression in pediatric patients with Systemic lupus erythematosus (SLE).
