■ターゲット情報 :

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IGFBP-1. The Human IGFBP-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Insulin-like growth factor-binding protein 1 (IGFBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBPs modulate the biological activities of IGF proteins.Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. High IGFBP-1 may be a marker of a catabolic state. Research shows that women with higher IGFBP-1 were more likely to have a low relative muscle mass. Higher IGFBP-1/IGF-1 serum ratio is significantly associated with poor prognosis in nasopharyngeal carcinoma(NPC) patients. Local IGFBP1 level was reported to affect the development of coronary artery plaque.