■ターゲット情報 :

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human XPNPEP2. The Human XPNPEP2 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
The membrane-bound X-prolyl aminopeptidase 2, also known as XPNPEP2, belongs to the peptidase M24B family, and has been reported to associate with Aminopeptidase P (APP) activity. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. APP is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. The translocation disrupts XPNPEP2, which encodes an XaaPro aminopeptidase that hydrolyzes N-terminal Xaa-Pro bonds. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).