カタログ製品コード : C-EK12322
Human PDGFRB/CD140b ELISA kit
24T | ¥55,200 | (¥2,300/T) (税別) |
48T | ¥69,200 | (¥1,442/T) (税別) |
96T | ¥78,000 | (¥813/T) (税別) |
標準納期 : 2週間 |
カタログ製品コード : C-EK12322
Human PDGFRB/CD140b ELISA kit
24T | ¥55,200 | (¥2,300/T) (税別) |
48T | ¥69,200 | (¥1,442/T) (税別) |
96T | ¥78,000 | (¥813/T) (税別) |
標準納期 : 2週間 |
メーカー名 | 遺伝子名 | 種交差性 | 測定範囲 | サンプル量 | 適用サンプル | ドキュメント |
---|---|---|---|---|---|---|
MultiSciences | PDGFRB/CD140b | Human | 625.00 - 40000 pg/ml | 20 μl | 血清、血漿、細胞培養上清 |
■保存方法 :
キットは未開封の場合、4℃で保管すること。 開封後は標準溶液を-20℃で保存し、他の試薬は4℃で保存すること。
■構成内容 :
96-well polystyrene microplate coated with a monoclonal antibody against PDGFRB |
Human PDGFRB Standard, lyophilized |
PDGFRB Detect Antibody |
Standard Diluent |
Assay Buffer (10×) |
Substrate (TMB) |
Stop Solution |
Washing Buffer (20×) |
Plate Covers |
■キーワード :
Homo sapiens,Human,Beta-type platelet-derived growth factor receptor,PDGF-R-beta,CD140 antigen-like family member B,PDGFRB,2.7.10.1,Beta-type platelet-derived growth factor receptor,CD140 antigen-like
■ターゲット情報 :
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human PDGFRB. The Human PDGFRB/CD140b ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Platelet-derived growth factor receptor beta (PDGFRB), also known as CD140b, together with the structurally homolog protein PDGFRA (CD140a) are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a kinase domain in their intracellular region.
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF‑BB, and PDGF‑AB isoforms have been shown to bind to PDGFRA and PDGFRB with different affinities. PDGFRA binds all three PDGF isoforms with high affinity, whereas PDGFRB binds PDGF-BB only with high-affinity. PDGF binding induces receptor homo-and hetero-dimerization and signal transduction. The expression of PDGFRA and PDGFRB are independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist.