カタログ製品コード : C-EK11592
Human VEGF R2/KDR ELISA kit
| 24T | ¥55,200 | (¥2,300/T) (税別) |
| 48T | ¥69,200 | (¥1,442/T) (税別) |
| 96T | ¥78,000 | (¥813/T) (税別) |
標準納期 : 2週間 |
製品詳細
| メーカー名 | 遺伝子名 | 種交差性 | 測定範囲 | サンプル量 | 適用サンプル | ドキュメント |
|---|---|---|---|---|---|---|
| MultiSciences | VEGF R2/KDR | Human | 62.50 - 4000 pg/ml | 100 μl (prediluted) | 血清、血漿、細胞培養上清 |
|
■保存方法 :
キットは未開封の場合、4℃で保管すること。 開封後は標準溶液を-20℃で保存し、他の試薬は4℃で保存すること。
■構成内容 :
| 96-well polystyrene microplate coated with a monoclonal antibody against VEGF R2 |
| Human VEGF R2 Standard, lyophilized |
| VEGF R2 Detect Antibody |
| Standard Diluent |
| Streptavidin-HRP |
| Assay Buffer (10×) |
| Substrate (TMB) |
| Stop Solution |
| Washing Buffer (20×) |
| Plate Covers |
■キーワード :
Homo sapiens,Human,Vascular endothelial growth factor receptor 2,VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,Protein-tyrosine kinase receptor flk-1,KDR,FLK1,2.7.10.1,KDR,CD309
■ターゲット情報 :
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human VEGF R2. The Human VEGF R2/KDR ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Vascular endothelial growth factor receptor-2 (VEGF R2), also known as kinase insert domain receptor (KDR), is a member of the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R2 is more widely distributed and expressed in all vessel-derived endothelial cells in comparison to VEGF R1. VEGF R2 binds VEGF-A (VEGF121, VEGF165, VEGF189 and VEGF206 splice variants), VEGF-C and VEGF-D. Soluble forms of VEGF R1 and VEGF R2 differ significantly from one another in terms of their abilities to block VEGF-induced cell proliferation and migration. Soluble VEGF R2 cannot compete with VEGF for binding to human endothelial cells expressing both VEGF R1 and VEGF R2, in contrast to soluble VEGF R1. Soluble VEGF R2 can only partially inhibit cell migration, whereas soluble VEGF R1 can almost completely block VEGF-induced cell proliferation and migration. The binding of VEGF to soluble VEGF R2, but not VEGF R1, is also dependent on heparin. The VEGF/VEGF R2 signaling pathway plays an important role in tumor angiogenesis and other diseases where "pathological angiogenesis" is involved. Inactivation of functional VEGF R2 by a blocking antibody can disrupt angiogenesis and prevent tumor cell invasion.
