■ターゲット情報 :

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human ANG-1. The Human Angiopoietin-1 / ANG-1 is for research use only. Not for diagnostic or therapeutic procedures.
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. Angiopoietin-1 (ANG-1) encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa, can form dimers, trimers, and tetramers. It is critical for vessel maturation, adhesion, migration, and survival. Deregulation of angiopoietin and the tyrosine kinase pathway is common in blood-related diseases such as diabetes, malaria, sepsis, and pulmonary hypertension. This is demonstrated by an increased ratio of ANG-2 and ANG-1 in blood serum.